The Kazak lab combines biochemistry, genetics and cell biology to study the molecular control of mammalian energy metabolism. We explore the underlying causes of obesity and cancer, with a focus on mitochondrial metabolism of adipocytes and cancer cells. We have generated novel genetically-engineered mouse models to accurately study cellular metabolism, in vivo. In the case of adipose tissue, we systematically examine mechanisms supporting adipocyte energy expenditure, which has tremendous promise for combating obesity. In the case of cancer, we are leveraging our expertise of mitochondrial biology and cellular energetics to explore novel metabolic pathways that are critical for tumorigenesis.
“A central lesson of science is that to understand complex issues (or even simple ones), we must try to free our minds of dogma and to guarantee the freedom to publish, to contradict, and to experiment. Arguments from authority are unacceptable.” Carl Sagan