1. Cluett TJ, Akman G, Reyes A, Kazak L, Mitchell A, Wood SR, Spinazzola A, Spelbrink JN and Holt IJ. Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication.
Nucleic Acids Research

2. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, and Rosen ED. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin.
Cell Metabolism

3. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, and Chouchani ET. Accumulation of systemic succinate controls activation of adipose tissue thermogenesis.

4. Paulo JA, Jedrychowski MP, Chouchani ET, Kazak L, and Gygi SP. Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy.

5. Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, and Spiegelman BM. Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.



1. Kazak L#, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina A, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, and Spiegelman BM#. Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity. #Co-corresponding author
Cell Metabolism

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2. Chouchani ET, Kazak L, and Spiegelman BM. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms.
Journal of Biological Chemistry

3. Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szypt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, and Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.

4. Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Betourne A, Kajimura S, Spiegelman BM, and Kirichok Y. Mitochondrial Patch-Clamp of Beige Adipocytes Reveals UCP1-positive and UCP1-negative Cells Both Exhibiting Futile Creatine.
Cell Metabolism



1. Chouchani ET*Kazak L*, Jedrychowski MP, Pierce KA, Lu GZ, Laznik-Bogoslavski D, Clish CB, Robinson AJ, Gygi SP, and Spiegelman BM. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. *Co-first author.



1. Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, and Spiegelman BM. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat.



1. Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, and Spiegelman BM. Tumor-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

2. Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, and Rosen ED. IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α.

3. Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, and Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis.



1. Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, and Holt IJ. A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties.
PLoS One

2. Reyes A, Kazak L, Wood SR, Yasukawa T, Jacbos HT, and Holt IJ. Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts.
Nucleic Acids Research

3. Kazak L#, Reyes A, Duncan A, Rorbach J, Wood SR, Brea-Calvo G, Gammage P, Robinson AJ, Minczuk M, and Holt IJ#. Alternative translation initiation augments the human mitochondrial proteome. #Co-corresponding author
Nucleic Acids Research



1. Kazak L#, Reyes A#, and Holt IJ#. Minimizing the damage: repair pathways keep mtDNA intact. #Co-corresponding author
Nature Reviews Molecular Cell Biology


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